RBL2/p130, a member of the retinoblastoma family of proteins, a well-known tumour suppressor gene in the Rb family, found inactivated in numerous cancers, has growth-suppressive properties and also deregulates in various types of cancer, especially in Pancreatic adenocarcinoma (PDAC), one of the most aggressive malignancies in humans [53]. This evidence concerns the gene RB1 and pancreatic adenocarcinoma.