CLCN3 and acute myeloid leukemia: However, both the increase in intracellular ROS (Fig. 8A) and the induction of apoptosis (Fig. 8B) in AML-12 cells induced by AuNPs and LPS-conditioned macrophage supernatants were not markedly suppressed by either an aquaporin 3 inhibitor (DFP00173) or a CLC3 inhibitor (DIDS), suggesting that extracellular ROS may not increase intracellular ROS in hepatocytes via direct transmembrane transport.