However, Zakerkish et al. showed that Propolis supplementation of 1000 mg/day for 90 days in T2DM patients could significantly decrease HbA1C, 2-h postprandial glucose (2hpp Glc), insulin, HOMA-IR, and HOMA-β levels but has no significant effect on FBS concentrations [32]. This evidence concerns the gene INS and type 2 diabetes mellitus.