Interestingly, recent studies have shown that inhibiting EGFR signalling may reduce tumour cell-intrinsic EGFR-induced programmed death-ligand 1 (PD-L1) upregulation, as well as extrinsic IFNγ-induced signals associated with CD8+ T cell infiltration into the tumour microenvironment (TME) [1, 8]. This evidence concerns the gene CD274 and neoplasm.