APOE and pulmonary fibrosis: These cells are functionally different from tissue-resident macrophages, recruiting and expressing profibrotic genes during lung fibrosis [47]. Next, the AM type in lung tissues, including anti-inflammatory AM (C2 and 8, APOE+, CD163+, and C1qb+), pro-inflammatory AM (C10, IL1β+, and C6 IL6+), and actively cycling AM expressing anti-inflammatory markers were found.