New decoy receptors include a trimeric hACE2-Fc variant30 and a high-affinity tetravalent format ACE2-Fc-TD.27 This variant also had a human IgG domain completely devoid of binding to Fcγ receptors (FcγRs) and complement protein C1q, thereby reducing the risk of antibody-dependent enhancement of infection.28 Ongoing work utilizes bat ACE2 orthologs.29 Here, ACE2 is linked to infection.