HMOX1 and brain ischemia: Along this line, it was reported that C3G demonstrates neuroprotective effects related to the suppression of oxidative stress, such as the reduction of lipoperoxidation and increased levels of the nonprotein thiol group, heme oxygenase-1 (HO-1), and gamma-glutamyl cysteine synthase (γ-GCS) in the cerebral tissues of rats with cerebral ischemia [59].