A slight increase in liver indices, especially AST, can be considered as a red flag for the development of nonalcoholic liver disease (NAFLD), commonly recognized as the hepatic manifestation of the MS, as reflected by the presence of ALT, AST and BMI in the surrogate marker of NAFLD hepatic steatosis index (HSI) [47,48]. The gene discussed is GPT; the disease is Hepatic steatosis.