These findings are supported by Paesano et al., who showed that combined administration of oral and intravaginal bovine lactoferrin in a sub-cohort of pregnant women with threatened PTD decreased IL-6 in both serum and cervicovaginal fluids, cervicovaginal prostaglandin F2a, and suppressed uterine contractility [46]. This evidence concerns the gene IL6 and Bjornstad syndrome.