Another study has shown that CML modified beta-lactoglobulin and HSA could not bind to RAGE receptor and could not also induce the gene expression of IL-6, IL-8, and TNFα in lung epithelial cells, coming in agreement with other studies suggesting that CML modified proteins are not RAGE ligands [165,320]. The gene discussed is ALB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.