Another study has shown that CML modified beta-lactoglobulin and HSA could not bind to RAGE receptor and could not also induce the gene expression of IL-6, IL-8, and TNFα in lung epithelial cells, coming in agreement with other studies suggesting that CML modified proteins are not RAGE ligands [165,320]. This evidence concerns the gene IL6 and chronic myelogenous leukemia, BCR-ABL1 positive.