The current study showed that MR prevents LPS-induced ALI, including the inflammatory response, inflammatory cell infiltration, and alveolar epithelial cell injuries without malnutrition via upregulating the CSE/H2S pathway, which is likely associated with inhibition of the TLR4/NF-κB/NLRP3 pathway (Figure 8). Here, NR3C2 is linked to malnutrition.