IL6 and cancer: In an intervention study of 41 hypercholesterolemic men and postmenopausal women who underwent high- and low-isoflavone soy food test phases, significantly higher interleukin-6 values after the high-isoflavone soy diet only appeared in women, indicating an estrogenic effect of soy isoflavones in enhancing the immune response among women, and thus the enhanced immune surveillance could lower risk of proinflammatory diseases such as CVD and cancer [44].