Thus, carbo-xylated Gas 6 and GRP take part in the protection of blood vessels against calcification, Gas 6 protects the kidneys from acute damage and plays a role in chronic kidney disease (CKD), GRP takes part in bone homeostasis and in delaying the development of osteoarthritis, whereas periostin takes part in all phases of fracture healing, and in early myocardial regeneration after myocardial infarction. This evidence concerns the gene GRP and chronic kidney disease.