The search strategy was carried out using the following key words: “curcumin and brain ischemia”, “brain ischemia and curcumin”, “curcumin and stroke”, stroke and curcumin”, “curcumin, neuroprotection, and brain ischemia”, “curcumin and amyloid”, “curcumin and tau protein”, “curcumin and gut microbiota”, “gut microbiota and curcumin”. Here, MAPT is linked to Stroke.