Fourth, research indicates that hyperphosphorylation of the tau protein with the final formation of neurofibrillary tangles also plays a key role in the development of post-ischemic brain neurodegeneration as in Alzheimer’s disease [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54]. The gene discussed is MAPT; the disease is Alzheimer disease.