TNFSF10 and glioblastoma: Further, the combination treatment of subtoxic concentrations of the endoplasmic reticulum (ER) stress-inducing agent 2,5-dimethyl-celecoxib (DMC) and DHER increased TRAIL-induced caspase-8 activation in TRAIL sensitive and insensitive glioblastoma multiforme cell lines (A172 and U87) [84].