Notably, 4C7 can promote the faster and stronger activation of caspase to induce apoptosis not only in TRAIL-sensitive human colon adenocarcinoma (Colo205, SW948, DLD-1, HCT-15 and CL-34), Burkitt’s lymphoma (BJAB) and the human ovarian carcinoma OVCAR-3, but also the TRAIL-resistant cancer cell line: pancreatic carcinoma (PANC-1) and breast cancer MCF-7 [79]. This evidence concerns the gene TNFSF10 and breast carcinoma.