RhTRAIL-C3 was a strong activator of pro-caspase 8 and enhanced the loss of mitochondrial membrane potential, resulting in DR4-mediated apoptosis in TRAIL-insensitive acute myelogenous leukemia and primary blast cell lines at a lower dose (1/6) compared to rhTRAIL WT [80]. The gene discussed is TNFRSF10A; the disease is acute myeloid leukemia.