NFKB1 and acute monocytic leukemia: For example, NF-κB p65 was found to be constitutively active in acute monocytic leukemia; therefore, studies have been conducted to regulate the proliferation and apoptosis of THP-1 cells in vitro and tumor growth in vivo by inhibiting the expression of NF-κB p65 for the treatment of acute monocytic leukemia [37].