Furthermore, as part of a family of inducible transcription factors, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) has been found to be a major inflammatory mediator of macrophages during RA; thus, it also mediates the induction of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6 [15,16]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.