CNR1 and Cognitive impairment: In line with this goal and with the topic of this review, we will now discuss work from our group and allied laboratories exploring the possibility of dissociating Δ9-tetrahydrocannabinol’s (THC) beneficial effects from its detrimental effects by using an optimized TM peptide disruptor to alter the CB1R-5HT2AR complex, i.e., the heterodimer formed by the cannabinoid CB1 and serotonin 5HT2A receptors that is responsible for the undesirable cognitive impairment [40].