These results indicate that the SK1 protein expression is not affected by the treatment of compound 10. In contrast, the apoptosis in colon cancer cells by compound 10 could be initiated due to the inhibition of SK1 enzyme activity ensuing a decreased pro-survival S1P lipid mediator level and increased proapoptotic sphingosine and ceramide level within colon cancer cells. This evidence concerns the gene MBTPS1 and colonic neoplasm.