Another hypoxia-associated major transcription factor, HIF2α (also called endothelial PAS domain protein 1 [EPAS1]) in pancreatic cancer, was targeted using NPs with siRNA loaded onto a polyethylenimine-poly(lactide-coglycolide) (PLGA)/poloxamer [48]. The gene discussed is EPAS1; the disease is familial pancreatic carcinoma.