Another study, which used both 4T1 and TUBO (a cloned BALB-neuT mouse mammary carcinoma cell line) bilateral syngeneic mouse models, showed that combined NP-mediated PDT with PD-L1 antibody completely eradicated the tumor, and there was a low (0.4%) metastasis rate of tumor nodules in the lungs [214]. The gene discussed is CD274; the disease is neoplasm.