The combination of PDT with other conventional vaccines (e.g., peptide and genetic vaccines), such as TLR5 agonist flagellin-adjuvanted tumor-specific peptide vaccination (FlaB-Vax) has revealed that this combination can enhance the infiltration of antigen-specific CD8+ T cells, effector memory CD8+ T cells, and IFN-γ expression in a B16-F10 tumor-bearing model [230]. The gene discussed is CD8A; the disease is neoplasm.