MMP2 and glioblastoma: Rutin also promoted reduction of GBM cell viability by inhibiting cell metabolism and migration, related to a reduction in filopodia-like structures on the cell surface, reduction of metalloproteinase (MMP-2) expression and activity, as well as an increase in intra- and extracellular expression of fibronectin, and intracellular expression of laminin, both matrix proteins [5].