TP53 and neoplasm: Due to their self-renewable and multipotent potential, the NSCs, which give rise to neuronal and glial progenitor cells, undergo combinations of specific genetic alterations, as in tumor suppressor genes (PTEN, Ink4a/Arf, Nf1, p53 and Rb1) and oncogenes (EGFR, kRas, Akt, PDGF and IDH1 ligands R132H), showing signs of neoplasia [24,27].