DDIT3 and glioblastoma: This flavonoid upregulated the death receptor 5 (DR5) related to TRAIL inducing C/EBP Homologous Protein (CHOP) transcription factor-dependent apoptosis in U-251MG; U-87MG, A-172, and U251N GBM cells, but not in healthy human astrocyte cells, in addition to reducing the expression of the proteasome-degraded anti-apoptotic FLICE-inhibitory protein long-form (FLIPL), FLICE-inhibitory protein short form (FLIPS) and survivin proteins [125].