MTOR and glioblastoma: Its glycosides such as flavone wogonoside induced death in SHG-44, A-172, U-87 MG and U-251 MG GBM cells, the last being more sensitive to treatment, cells presenting features of autophagy followed by mitochondrial apoptosis associated with the activation of the p38 MAPK and inhibition of PI3K/Akt/mTOR/p70S6K pathways [134].