MMP9 and glioblastoma: In another study, Aroui and collaborators [152] demonstrated that naringenin inhibited the invasion and migration of U-251 GBM cells through the negative regulation of MMP-2 and matrix metalloproteinase-9 (MMP-9) expression and inactivation of p38 signaling pathway, involved in the regulation of many cellular processes, including differentiation, growth and cell death [153].