TNF and glioma: Moreover, in a more recent study developed by da Silva et al. [10], it was demonstrated that the treatment of rat C6 glioma cells with rutin or with its aglycone quercetin induced the inhibition of proliferation and migration, and also induced microglia chemotaxis that was associated to the upregulation of TNF and the downregulation of IL-10, at protein and mRNA expression levels, associated with the upregulation of mRNA expression for chemokines CCL2, CCL5 and CX3CL1.