TP53 and neoplasm: Other important aspects of GBM/astrocyte communication, are direct cell-cell contacts through communicating junctions, ion channels, microtubules and tunneling nanotubes [36,38] and indirect interactions through the secretion of molecules, the release of gliotransmitters and extracellular vesicles (EVs), which stimulate healthy astrocytes to internalize them and to acquire a tumor support phenotype via p53 and MYC signaling pathways [39].