Rutin (quercetin-3-O-rutinoside), abundant in beans of the Brazilian plant Dimorhandra mollis Bent., presented antiproliferative, proapoptotic and morphogenic effects on GL-15 human GBM cells, associated with decreased levels of ERK1/2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle [118]. The gene discussed is MAPK3; the disease is glioblastoma.