SERPINE1 and asthma: Among the studies that relate cell senescence and asthma, it is worth mentioning the research performed by Wu et al. [58], who observed cellular senescence induced by Thymic Stromal Lymphopoietin (TSLP) with elevated levels of P21 and P16 in human epithelial cells, being essential for the remodeling of the airways in vitro; as well as the study with a plasminogen activator inhibitor (PAI-1), a mediator of cell senescence and fibrosis, which could activate p53 and mediate the senescence of type II alveolar cells (ATII) induced by bleomycin and doxorubicin [59].