It has been shown that CUR inhibits transcription factors (NF-KB, AP-1, and STAT3) highly expressed in cancer cells, and genes involved in processes such as proliferation (COX-2, c-Myc, and cyclin D1), survival (Bcl-2, Bcl-XL), invasion (MM9), and metastasis (ICAM-1, ELAM-1, VCAM-1). The gene discussed is NFKB1; the disease is cancer.