Due to the significant role of NRP-1 in angiogenesis and the relatively well-known mechanisms of the formation and action of the VEGF-A165/NRP-1 complex, the design of compounds that block the formation of this complex is an interesting direction in the search for anti-angiogenic and anti-cancer drugs [4,19,20,21,22,23,24,25]. The gene discussed is NRP1; the disease is cancer.