Analysis in SCLC and non-small cell lung cancer (NSCLC) cell lines showed that ASO-4625, which has no mismatching nucleotides to Bcl-2 but three mismatching nucleotides to Bcl-xL, had the strongest bispecific activity, inhibiting the expression of both proteins and inducing cell death [63]. The gene discussed is BCL2; the disease is small cell lung carcinoma.