TNFAIP3 and allergic asthma: Additionally, Luo et al. also used PLGA to synthesize nanoparticles containing A20, or tumor necrosis factor alpha-induced protein 3 (TNFAIP3), and ovalbumin (OVA) to form an intranasal PLGA-OVA+A20 nanovaccine, which relieved allergic asthma in BALB/c mice by increasing production of Treg cells better than the free form of OVA+A20 [143].