Benzthiazide (thiazide diuretic), entacapone (catechol-O-methyltransferase inhibitor, Parkinson’s disease) and lodoxamide (mast cell stabilizer, antiallergic) emerged as the best candidates for development as anti-virulence agents in infections with pathogens form the Clostridium, Pseudomonas, Vibrio, and Streptomyces genuses. The gene discussed is COMT; the disease is infection.