Among the 386 HS-associated DEGs, 101 genes were enriched in the cytokine–cytokine (C–C) receptor interaction pathway (−log10 = 2.5 × 10−74), 51 in the JAK-STAT signaling pathway (2.6 × 10−34), 39 in the chemokine signaling pathway (2.7 × 10−18), 32 in the IL-17 signaling pathway (1.8 × 10−22), 31 in the Th17 cell differentiation pathway (2.6 × 10−18), 28 in the Toll-like receptor (TLR) pathway (2.2 × 10−16) and 26 in the inflammatory bowel disease pathway (3.6 × 10−26) (Figure S1). Here, SOAT1 is linked to inflammatory bowel disease.