Combining different post-SELEX biochemical approaches, we were able to identify EGFR and platelet-derived growth factor receptor beta (PDGFRβ) as the molecular targets of CL4 and Gint4.T aptamers, respectively, with the first coming from the selection on NSCLC cells [75] and the second from that on GBM cells [76]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.