At the same time, data in the literature point out that stem cells are able to modulate processes related to the attenuation of renal injury in kidney diseases, including through the regulation of Klotho expression, through their characteristic properties [266], although the improvement of their therapeutic efficacy in vivo is challenging and still requires the development of strategies, as reviewed by Yun C. W et al. [293]. This evidence concerns the gene KL and kidney disorder.