Regarding this approach, there are also other studies involving rodent models for diabetic kidney disease (DKD) that show the amelioration of the disease after the delivery of Klotho, which might be associated with the inhibition of RAAS activation and the Wnt/β-catenin pathway [225] and the improvement of creatinine clearance, proteinuria and tubulointerstitial damage in animals with Ang-II infusion [226]. This evidence concerns the gene KL and diabetic kidney disease.