In glioblastoma and neuroblastoma, JMJD6 upregulates target gene transcription by forming a complex with Bromodomain-containing protein 4 (BRD4)—a transcriptional and epigenetic regulator associated with cell cycle control—and demethylating the histone H4 at arginine 3 (H4R3) target gene antipause enhancers, leading to RNA polymerase II release from promoter-proximal pause regions and consequently to aberrant gene expression [146,147,148]. The gene discussed is BRD4; the disease is glioblastoma.