PFKFB3 and neoplasm: This observation is supported by the fact that PFK-2/FBPase-2 mRNAs are overexpressed in human lung cancers [36] and by the fact that PFK-2/FBPase-2 enzymes are induced in hypoxia [37,38,39], an important component of the tumor microenvironment that regulates, for example, tumor angiogenesis and metastasization [18].