The live streptococcal strains S. pyogenes 21, S. pyogenes 7, S. pyogenes GUR, and S. pyogenes GURSA1, nerve growth factor (NGF) and the cathelicidin family antimicrobial peptides LL-37 and PG-1 show strong oncolytic effects, superior to the effect of chemotherapeutic drugs on C6 glioma cells in vitro. The gene discussed is NGF; the disease is glioma.