TP53 and neoplasm: In other types of tumor cells, it was shown that PG-1 induces the formation of transmembrane pores, causing an intracellular flow of Ca2+, which, in turn, triggers the activation of the protein and gene p53, caspase-3, an inhibitor of cyclin-dependent kinase 1A (CDKN1A) and the inhibition of the proliferating cell nuclear antigen (PCNA), leading eventually to apoptosis [40].