In vivo, intragastric administration with oleocanthal (7.5 mg/kg daily for seven weeks) suppressed the initiation and incidence of mammary carcinogenesis in MMTV-PyVT mice developing spontaneous mammary tumors and in a breast cancer patient-derived xenograft model, concomitantly with transcriptomic changes in tumors and with the downregulation of Myc being a key event [155]. The gene discussed is MYC; the disease is breast cancer.