MTOR and breast cancer: In relation to the potential activity of secoiridoids as epigenetic modulators, in vitro screening in different breast cancer cell lines has revealed that decarboxymethyl oleuropein aglycone had inhibitory effects of mTOR and DNA-methyl-transferase (DNMT) and further in silico analyses suggested that this secoiridoid could act as an ATP-competitive mTOR inhibitor and could block the SAM-dependent methylation activity of DNMTs [138].