On the other hand, On et al. also developed a non-toxic indocyanine green (ICG) and cyanine 5.5 (Cy5.5)-coupled tumor-targeting CNP-based system, which displayed outstanding tumor accumulation and prolonged biodistribution profiles in both rabbit squamous cancer cell (VX2) tumor-bearing mouse and rabbit models probably due to the EPR effects of CNP [71]. This evidence concerns the gene CNP and neoplasm.