RSV showed several positive effects on the management of obesity, inducing mitochondrial biogenesis and oxidative phosphorylation via the activation of peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) via SIRT1 deacetylase, leading to improved insulin sensitivity [100], and by increasing the expression of SIRT1, a reduction in the size of adipocytes, showing an anti-lipolytic effect [101]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.