IL1B and Alzheimer disease: In a 2016 study in which a memory and learning deficit was induced in a mouse model by microinfusion into the hippocampus of β-amyloid1-42, the main constituent of amyloid plaques that forms during the exerts of AD [116], higher dose (40 mg/kg) of RSV was shown to significantly improve the memory of rats, and to decrease the expression of apoptotic and inflammatory cytokines, such as IL-1β and IL-6, acting on T cells.