Neuroinflammation is one of the major contributing factors in exacerbating neurodegeneration and depression, which, especially in combination with chronic stress, can increase the level of pro-inflammatory cytokines, such as TNF-α and IL-1β, leading to the development of diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) [109,110]. This evidence concerns the gene TNF and Parkinson disease.