VWF and Thrombocytopenia: The aptamer-based anti-von Willebrand factor (ARC1779) is a potent inhibitor of the VWF A1 domain interaction with GPIb and effectively prevents the consumption of VWF and platelets in response to desmopressin in VWD type 2B and prevents desmopressin-induced thrombocytopenia in VWD type 2B [62].