NDC80 and neoplasm: A relentless pursuit of developing a clinical candidate for destabilizing the Hec1/Nek2 axis has led to the discovery of TAI-95 (Table 1, Entry 20), a highly effective compound, when administered orally and/or intravenously, in suppressing tumor in mice bearing human MDA-MB-231, BT474, and MCF7 xenografts [155,156].