NEK2 and plasma cell myeloma: Yang et al. showed that while aldehyde dehydrogenase 1-A1 (ALDH1A1) overexpression in myeloma cells led to overexpression of the Nek2 kinase both at the mRNA and protein levels with enhanced drug resistance, knock down of Nek2 expression by shRNA decreased drug efflux pump activity reducing drug resistance [74].