Due to the fact that the antioxidant status of cancer cells may be of key importance for the effectiveness of anticancer therapy, in the present work, we decided to investigate the effect of kaempferol and its glycoside derivatives on the expression of the NFE2L2 gene and its downstream genes: HO-1, NQO1, SOD1, and SOD2 in HL-60 cells treated with etoposide. Here, SOD1 is linked to cancer.