Sepsis has been shown to be associated with a decrease in circulating MAIT cells [41], while MAIT cells from acute sepsis patients (at Day 1 post-admission) show notably modified phenotypic profiles compared to both MAIT cells from healthy donors, and MAIT cells from the same patients at Day 90 post-admission, suggesting acute MAIT cell responses which revert to the status quo ante following infection resolution; this includes significantly elevated expression of CD69 and reduced capacity for IFNγ production in response to Escherichia coli infection in vitro [38]. This evidence concerns the gene IFNG and infection.