LAIR1 and adult T-cell leukemia/lymphoma: Watanabe et al. identified differentially methylated positions (DMPs) specific to HTLV-infected cells, and identified those that correlated with ATLL development and progression, including CpG islands in genes encoding thymocyte-expressed molecule (THEMIS), leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), and ring-type E3 ubiquitin transferase 130 (RNF130), which negatively regulate T-cell receptor (TCR) signaling [40].