Deubiquitylation inhibits plus-strand transcription, the modification of histones at genes for p300, SET domain-containing 2 (SET2), lysine demethylase 6A (KDM6A), and switch/sucrose non-fermentable complex (SWI/SNF)-mediated chromatin remodeling, which are known to be frequently altered in human cancers, including other T-cell neoplasms [76]. The gene discussed is SETD2; the disease is T-cell and NK-cell neoplasm.