However, transient or lasting dysbioses in the synovium or synovial fluid could contribute to RA, especially if oral pathobionts such as Pg, or other pathobionts from gut or lung microbiomes, deliver danger signals to long-lived presenting cells, including cells with stem cell properties, such as tissue-resident macrophages of embryologic origin [83], and/or mesenchymal stem cells of synovial tissues [44]. Here, JUP is linked to rheumatoid arthritis.