The potential relationship between HPV infection and SRSF1 overexpression in BCCs is undoubtedly a suggestive hypothesis that deserves further investigation; however, we speculate that the exclusive nuclear localization of the protein found in the cases from our series contrasts with the data reported by Mole et al. [26], even if sometimes the results from in vitro and ex vivo studies can be discordant and the degree of differentiation of the keratinocyte lines used by the authors [26] does not overlap with that of BCC cells. This evidence concerns the gene SRSF1 and skin basal cell carcinoma.