NLRP3 and chronic obstructive pulmonary disease: The NLRP3 inflammasome induces mitochondrial damage and mitophagy in COPD epithelium, resulting in marked impairment of MAVS-mediated antiviral immunity, thus regulating the production of antiviral type I and type III IFNs, and pro-inflammatory cytokines following viral infection [53,54,55].