In a study by Broncaccio at al., ovothiol, known as a natural product which includes sulfur-containing compounds, showed antifibrotic effect reducing fibro-genic markers involved in the progression of liver fibrosis, such as α-smooth muscle actin (α-SMA), transforming growth factor (TGF-β) and tissue metalloproteinase inhibitor (TIMP-1) [45]. This evidence concerns the gene ACTA1 and Hepatic fibrosis.