CHI3L1 and early-onset autosomal dominant Alzheimer disease: Mattsson et al. (2017), analysed CSF samples from AD patients, patients with other dementias and MCI and healthy controls, finding higher chitotriosidase in the Alzheimer’s disease group, when compared to controls and patients with stable MCI, but they did not find a statistically significant difference in the YKL-40 levels between groups [25].