The SAW biosensor with either a ST-quartz or LiTaO3 substrate, has been reported for the detection of biomarkers for the early diagnosis of cancer, such as the carcinoembryonic antigen (CEA), prostate-specific membrane antigen (PSMA), epidermal growth factor (EGF), B-cell lymphoma, and exosomes [213,252,253,258,260,271,273,286]. Here, CEACAM5 is linked to B-cell non-Hodgkin lymphoma.