NOTCH4 and breast cancer: The QCM Au electrode surface coated with Poly (2-hydroxyethyl methacrylate) nanoparticles (PHEMA-NPs), were used for the immobilization of antibodies specific to the notch-4 receptor for the detection of the metastatic potential of human breast cancer cells with an overexpression of the Notch 4 receptor [114,141].