Furthermore, common genetic variants, including complement factor H (CFH), complement factor I (CFI), complement factor B (CFB), complement 3 (C3) and human serine protease high temperature requirement A1 (HTRA1) [186], as well as the substitution of serine for alanine at codon 69 (A69S) in age-related maculopathy susceptibility 2 (ARMS2) gene positioned at a locus on chromosome 10q26 [187], are associated with AMD. The gene discussed is C3; the disease is age-related macular degeneration.