CASP3 and neoplasm: Of note, sections of the tumour that came into direct contact with ABT-263, being locally and directly delivered, stained positive for cleaved Caspase 3 (Figure 5d), suggesting that ABT-263 can induce apoptosis in MB tumours when high enough local concentrations, here a 5 μM solution in a 15 μL volume, can be achieved.