We are the first to report that mirogabalin enhances the mRNA expression of spinal antinociceptive factors, such as IL-10 and IL-18BP, and reduces the mRNA expression of pronociceptive substance P. Importantly, mirogabalin administered with morphine, buprenorphine, and oxycodone induces better antinociception in a neuropathic pain model, which suggests that it can be used clinically, similar to pregabalin and gabapentin. Here, IL10 is linked to neuropathic pain.