HTT and neurodegenerative disease: Of note, the aggregation of mutant neurodegenerative disease proteins such as beta-amyloid, alpha-synuclein and huntingtin in brains were reported to play a pathogenic role in neurodegenerative diseases such as Alzheimer’s disease (AD), PD and Huntington’s disease, respectively; however, the available compounds facilitating the degradation of these proteins remains scarce.