S100B and neurodegenerative disease: According to our previous studies and the reported literature, Bai, Hed, and Nef are able to reduce the level of mutant neurodegenerative disease proteins such as HTT74, tau P301L or A53T α-syn in vivo or in vitro [24,25,44]; therefore, the in vitro protective effects of encapsulated Exo-compounds including Exo-Bai, Exo-Hed and Exo-Nef were compared with the compounds alone.